Matthew Shannon

Matthew Shannon

Assistant Professor of Biochemistry

Matthew Shannon, PhD, is a biophysical chemist, who is interested in using spectroscopic methods, primarily Nuclear Magnetic Resonance, to study macromolecules at atomic resolution.

  • PhD, chemistry, The Ohio State University
  • BS, chemistry, University of Pittsburgh

Contact

Course Sampling

  • Biochemistry I/II
  • General Chemistry I/II
  • Spectroscopy

Areas of Expertise

  • Biophysical chemistry
  • NMR spectroscopy
  • Protein structure, dynamics and interactions

Biography

Matthew Shannon, PhD, grew up in Pittsburgh, PA, and obtained his undergraduate degree in chemistry at the University of Pittsburgh. At Pitt, he developed a passion for magnetic resonance spectroscopy while working with Dr. Sunil Saxena. He then earned his PhD in physical chemistry at The Ohio State University under the supervision of Dr. Christopher Jaroniec. At OSU, he used solid-state Nuclear Magnetic Resonance to probe the structure and dynamics of biomolecules (e.g., chromatin and prion amyloids). After earning his PhD, he began his academic career at Denison University. In his two years at Denison as a Visiting Professor, he gained invaluable experience conducting research with undergraduates and teaching introductory chemistry and biochemistry courses. He joined Stetson in the fall of 2020 as an Assistant Professor of Biochemistry. He enjoys sharing his interdisciplinary background with students both inside the classroom and in the labora tory. In his free time, he also enjoys volleyball, basketball, running, watersports and spending time at the beach. He hopes to find time to do all these activities in sunny Florida.

Research

  • Design of advanced undergraduate labs (e.g., biochemistry and spectroscopy) to improve pedagogy
  • Using paramagnetic metal ions to probe distances in proteins using NMR
  • NMR and computational methods to probe protein-ligand interactions

Publications

  • D.W. Conroy, Y. Xu, H. Shi, N. Gonzalez Salguero, R.N. Purosottam, M.D. Shannon, H.M. Al-Hashimi, C.P. Jaroniec, Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy, Nature Methods, submitted.
  • M. Zandian, N. Gonzalez Salguero, M.D. Shannon, R.N. Purusottam, T. Theint, M.G. Poirier, C.P. Jaroniec, Conformational dynamics of histone H3 tails in chromatin, J. Phys. Chem. Lett. 2021, 12, 6174-6181.
  • S.O. Rabdano, M.D. Shannon, S.A. Izmailov, N. Gonzalez Salguero, M. Zandian, R.N. Purusottam, M.G. Poirier, N.R. Skrynnikov, C.P. Jaroniec, Histone H4 tails in nucleosomes: a fuzzy interaction with DNA, Angew. Chem. Int. Ed. 2021, 60, 6480-6487.
  • M.D. Shannon, T. Theint, D. Mukhopadhyay, K. Surewicz, W.K. Surewicz, D. Marion, P. Schanda, C.P. Jaroniec, Conformational dynamics in the core of human Y145Stop prion protein amyloid probed by relaxation dispersion NMR, ChemPhysChem 2019, 20, 311-317.
  • D. Mukhopadhyay, P.S. Nadaud, M.D. Shannon, C.P. Jaroniec, Rapid quantitative measurements of paramagnetic relaxation enhancements in Cu(II)-tagged proteins by proton-detected solid-state NMR spectroscopy, J. Phys. Chem. Lett. 2017, 8, 5871-5877.
  • L.A. Baldwin, J.W. Crowe, M.D Shannon, C.P. Jaroniec, P.L. McGrier, 2D covalent organic frameworks with alternating triangular and hexagonal pores, Chem. Mater. 2015, 27, 6169-6172.
  • T.F. Cunningham, M.D. Shannon, M.R. Putterman, R.J. Arachchige, I. Sengupta, M. Gao, C.P. Jaroniec, S. Saxena, Cysteine specific Cu2+ chelating tags used as paramagnetic probes in double electron electron resonance, J. Phys. Chem. B 2015, 119, 2839-2843.