Jean Smith

Jean Smith

Assistant Professor of Biology

After growing up in Gainesville, FL, Dr. Jean Smith moved north to attend The Johns Hopkins University in Baltimore, MD. As an undergraduate she fell in love with molecular biology during an introductory course her freshman year and went on to begin her research career studying yeast calcium signaling pathways in the laboratory of Dr. Kyle Cunningham.

  • Postdoctoral research fellow, The University of North Carolina at Chapel Hill
  • Ph.D., Molecular Biology, Princeton University
  • B.S., Molecular and Cellular Biology, The Johns Hopkins University

Contact

Course Sampling

  • Introductory biology
  • Microbiology

Areas of Expertise

  • Molecular Biology
  • Cell Biology
  • Genetics
  • Fungal Biology

Biography

After growing up in Gainesville, FL, Dr. Jean Smith moved north to attend The Johns Hopkins University in Baltimore, MD. As an undergraduate she fell in love with molecular biology during an introductory course her freshman year and went on to begin her research career studying yeast calcium signaling pathways in the laboratory of Dr. Kyle Cunningham. She also discovered her passion for teaching while serving as a Teaching Assistant for the Introductory Chemistry labs. In 2011, she graduated with a B.S. in Molecular and Cellular Biology and went on to pursue her Ph.D. in Molecular Biology at Princeton University. There she continued working on yeast cell biology in the laboratory of Dr. Mark Rose, ultimately uncovering novel mechanisms for yeast cell fusion. As a graduate student she was also an assistant instructor for multiple courses, for one of which she earned a teaching award. She was also very involved with Princeton's McGraw Center for Tea ching and Learning, being selected to complete a year-long pedagogy seminar and later hired as a Graduate Teaching Fellow to help train other teachers. After receiving her doctorate, Dr. Smith became a postdoctoral fellow at the University of North Carolina at Chapel Hill working in the laboratory of Dr. Amy Gladfelter. At UNC she built upon her graduate research experiences by studying the cellular organization of multinucleate cells, including filamentous fungi and mammalian muscle. She also taught an upper level honors seminar for students completing independent research, teaching them to write scientifically and present their research professionally.

Research

  • Fungal cell biology and genetics
  • Cell-cell fusion in budding yeast and filamentous fungi
  • Functional diversity of different filamentous fungi isolates

Publications

  • Langdon, E. M., Qiu, Y., Ghanbari Niaki, A., McLaughlin, G. A., Weidmann, C., Gerbich, T. M., Smith, J. A., Crutchley, J. M., Termini, C. M., Weeks, K. M., Myong, S., & Gladfelter, A. S. mRNA structure determines specificity of a polyQ-driven phase separation. Science. 2018 doi: 10.1126/science.aar7432
  • Smith, J. A.,* Hall, A. E.,* & Rose, M.D. Membrane curvature directs the localization of Cdc42p to novel foci required for cell-cell fusion. The Journal of Cell Biology. 2017 216(12):3971-3980
  • Smith, J. A. & Gladfelter, A. S. Lessons from Yeast on How to Avoid Stress Eating. Developmental Cell. 2017 43(1):3-5
  • Smith, J. A. & Rose, M. D. Kel1p Mediates Yeast Cell Fusion through a Fus2p and Cdc42p-Dependent Mechanism. Genetics. 2016 202(4):1421-35
  • Stein, R.,* Smith, J. A.,* & Rose, M. D. An Amphiphysin-Like Domain in Fus2p Is Required for Rvs161p Interaction and Cortical Localization. G3: Genes|Genomes|Genetics. 2015 6(2): 337-49
    *These authors contributed equally to this work.